APLS
Price
$19.45
Change
-$0.28 (-1.42%)
Updated
Nov 19, 04:59 PM (EDT)
Capitalization
2.5B
105 days until earnings call
Intraday BUY SELL Signals
VNDA
Price
$5.14
Change
-$0.21 (-3.93%)
Updated
Nov 19, 04:59 PM (EDT)
Capitalization
315.58M
84 days until earnings call
Intraday BUY SELL Signals
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APLS vs VNDA

Header iconAPLS vs VNDA Comparison
Open Charts APLS vs VNDABanner chart's image
Apellis Pharmaceuticals
Price$19.45
Change-$0.28 (-1.42%)
Volume$46.28K
Capitalization2.5B
Vanda Pharmaceuticals
Price$5.14
Change-$0.21 (-3.93%)
Volume$28.77K
Capitalization315.58M
APLS vs VNDA Comparison Chart in %
APLS
Daily Signal:
Gain/Loss:
VNDA
Daily Signal:
Gain/Loss:
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APLS vs. VNDA commentary
Nov 20, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is APLS is a Hold and VNDA is a Hold.

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COMPARISON
Comparison
Nov 20, 2025
Stock price -- (APLS: $19.73 vs. VNDA: $5.34)
Brand notoriety: APLS and VNDA are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: APLS: 81% vs. VNDA: 728%
Market capitalization -- APLS: $2.46B vs. VNDA: $304.05M
APLS [@Biotechnology] is valued at $2.46B. VNDA’s [@Biotechnology] market capitalization is $304.05M. The market cap for tickers in the [@Biotechnology] industry ranges from $106.82B to $0. The average market capitalization across the [@Biotechnology] industry is $2.15B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

APLS’s FA Score shows that 0 FA rating(s) are green whileVNDA’s FA Score has 1 green FA rating(s).

  • APLS’s FA Score: 0 green, 5 red.
  • VNDA’s FA Score: 1 green, 4 red.
According to our system of comparison, APLS is a better buy in the long-term than VNDA.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

APLS’s TA Score shows that 5 TA indicator(s) are bullish while VNDA’s TA Score has 6 bullish TA indicator(s).

  • APLS’s TA Score: 5 bullish, 5 bearish.
  • VNDA’s TA Score: 6 bullish, 4 bearish.
According to our system of comparison, VNDA is a better buy in the short-term than APLS.

Price Growth

APLS (@Biotechnology) experienced а +1.10% price change this week, while VNDA (@Biotechnology) price change was +21.92% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was -2.17%. For the same industry, the average monthly price growth was -5.68%, and the average quarterly price growth was +64.91%.

Reported Earning Dates

APLS is expected to report earnings on Mar 04, 2026.

VNDA is expected to report earnings on Feb 11, 2026.

Industries' Descriptions

@Biotechnology (-2.17% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
APLS($2.5B) has a higher market cap than VNDA($316M). VNDA has higher P/E ratio than APLS: VNDA (126.00) vs APLS (54.79). VNDA YTD gains are higher at: 11.482 vs. APLS (-38.186). APLS has higher annual earnings (EBITDA): 93.4M vs. VNDA (-113.07M). APLS has more cash in the bank: 479M vs. VNDA (294M). VNDA has less debt than APLS: VNDA (10.9M) vs APLS (475M). APLS has higher revenues than VNDA: APLS (1.02B) vs VNDA (212M).
APLSVNDAAPLS / VNDA
Capitalization2.5B316M790%
EBITDA93.4M-113.07M-83%
Gain YTD-38.18611.482-333%
P/E Ratio54.79126.0043%
Revenue1.02B212M479%
Total Cash479M294M163%
Total Debt475M10.9M4,358%
FUNDAMENTALS RATINGS
APLS vs VNDA: Fundamental Ratings
APLS
VNDA
OUTLOOK RATING
1..100
6823
VALUATION
overvalued / fair valued / undervalued
1..100
82
Overvalued
90
Overvalued
PROFIT vs RISK RATING
1..100
100100
SMR RATING
1..100
5593
PRICE GROWTH RATING
1..100
6463
P/E GROWTH RATING
1..100
492
SEASONALITY SCORE
1..100
9050

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

APLS's Valuation (82) in the Medical Distributors industry is in the same range as VNDA (90) in the Biotechnology industry. This means that APLS’s stock grew similarly to VNDA’s over the last 12 months.

APLS's Profit vs Risk Rating (100) in the Medical Distributors industry is in the same range as VNDA (100) in the Biotechnology industry. This means that APLS’s stock grew similarly to VNDA’s over the last 12 months.

APLS's SMR Rating (55) in the Medical Distributors industry is somewhat better than the same rating for VNDA (93) in the Biotechnology industry. This means that APLS’s stock grew somewhat faster than VNDA’s over the last 12 months.

VNDA's Price Growth Rating (63) in the Biotechnology industry is in the same range as APLS (64) in the Medical Distributors industry. This means that VNDA’s stock grew similarly to APLS’s over the last 12 months.

VNDA's P/E Growth Rating (2) in the Biotechnology industry is somewhat better than the same rating for APLS (49) in the Medical Distributors industry. This means that VNDA’s stock grew somewhat faster than APLS’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
APLSVNDA
RSI
ODDS (%)
Bullish Trend 2 days ago
73%
Bearish Trend 2 days ago
90%
Stochastic
ODDS (%)
Bullish Trend 2 days ago
78%
Bullish Trend 2 days ago
80%
Momentum
ODDS (%)
Bearish Trend 2 days ago
85%
Bullish Trend 2 days ago
69%
MACD
ODDS (%)
Bearish Trend 2 days ago
82%
Bullish Trend 2 days ago
79%
TrendWeek
ODDS (%)
Bullish Trend 2 days ago
79%
Bullish Trend 2 days ago
74%
TrendMonth
ODDS (%)
Bearish Trend 2 days ago
85%
Bullish Trend 2 days ago
73%
Advances
ODDS (%)
Bullish Trend 8 days ago
81%
Bullish Trend 2 days ago
69%
Declines
ODDS (%)
Bearish Trend 2 days ago
80%
Bearish Trend 13 days ago
69%
BollingerBands
ODDS (%)
Bullish Trend 2 days ago
78%
Bearish Trend 2 days ago
85%
Aroon
ODDS (%)
Bullish Trend 2 days ago
82%
Bullish Trend 2 days ago
63%
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APLS
Daily Signal:
Gain/Loss:
VNDA
Daily Signal:
Gain/Loss:
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Correlation & Price change

A.I.dvisor indicates that over the last year, VNDA has been loosely correlated with APLS. These tickers have moved in lockstep 43% of the time. This A.I.-generated data suggests there is some statistical probability that if VNDA jumps, then APLS could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To VNDA
1D Price
Change %
VNDA100%
+21.36%
APLS - VNDA
43%
Loosely correlated
-1.87%
ANNX - VNDA
41%
Loosely correlated
+6.29%
ADMA - VNDA
40%
Loosely correlated
+1.75%
IVF - VNDA
40%
Loosely correlated
-4.96%
NEVPF - VNDA
38%
Loosely correlated
N/A
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