FOLD
Price
$7.99
Change
-$0.03 (-0.37%)
Updated
Sep 12 closing price
Capitalization
2.46B
51 days until earnings call
SYRE
Price
$15.65
Change
-$0.55 (-3.40%)
Updated
Sep 12 closing price
Capitalization
945.28M
52 days until earnings call
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FOLD vs SYRE

Header iconFOLD vs SYRE Comparison
Open Charts FOLD vs SYREBanner chart's image
Amicus Therapeutics
Price$7.99
Change-$0.03 (-0.37%)
Volume$2.88M
Capitalization2.46B
Spyre Therapeutics
Price$15.65
Change-$0.55 (-3.40%)
Volume$431.18K
Capitalization945.28M
FOLD vs SYRE Comparison Chart in %
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FOLD
Daily Signalchanged days ago
Gain/Loss if bought
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SYRE
Daily Signalchanged days ago
Gain/Loss if bought
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FOLD vs. SYRE commentary
Sep 15, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is FOLD is a Hold and SYRE is a StrongBuy.

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COMPARISON
Comparison
Sep 15, 2025
Stock price -- (FOLD: $7.99 vs. SYRE: $15.65)
Brand notoriety: FOLD and SYRE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: FOLD: 73% vs. SYRE: 89%
Market capitalization -- FOLD: $2.46B vs. SYRE: $945.28M
FOLD [@Biotechnology] is valued at $2.46B. SYRE’s [@Biotechnology] market capitalization is $945.28M. The market cap for tickers in the [@Biotechnology] industry ranges from $101.15B to $0. The average market capitalization across the [@Biotechnology] industry is $1.9B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

FOLD’s FA Score shows that 0 FA rating(s) are green whileSYRE’s FA Score has 0 green FA rating(s).

  • FOLD’s FA Score: 0 green, 5 red.
  • SYRE’s FA Score: 0 green, 5 red.
According to our system of comparison, FOLD is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

FOLD’s TA Score shows that 2 TA indicator(s) are bullish while SYRE’s TA Score has 4 bullish TA indicator(s).

  • FOLD’s TA Score: 2 bullish, 5 bearish.
  • SYRE’s TA Score: 4 bullish, 4 bearish.
According to our system of comparison, SYRE is a better buy in the short-term than FOLD.

Price Growth

FOLD (@Biotechnology) experienced а 0.00% price change this week, while SYRE (@Biotechnology) price change was -7.94% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +1.38%. For the same industry, the average monthly price growth was +7.84%, and the average quarterly price growth was +35.14%.

Reported Earning Dates

FOLD is expected to report earnings on Nov 05, 2025.

SYRE is expected to report earnings on Nov 06, 2025.

Industries' Descriptions

@Biotechnology (+1.38% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
FOLD($2.46B) has a higher market cap than SYRE($945M). FOLD YTD gains are higher at: -15.180 vs. SYRE (-32.775). FOLD has higher annual earnings (EBITDA): 33.1M vs. SYRE (-222.15M). SYRE has more cash in the bank: 527M vs. FOLD (231M). SYRE has less debt than FOLD: SYRE (0) vs FOLD (443M). FOLD has higher revenues than SYRE: FOLD (571M) vs SYRE (0).
FOLDSYREFOLD / SYRE
Capitalization2.46B945M261%
EBITDA33.1M-222.15M-15%
Gain YTD-15.180-32.77546%
P/E RatioN/A1.72-
Revenue571M0-
Total Cash231M527M44%
Total Debt443M0-
FUNDAMENTALS RATINGS
FOLD vs SYRE: Fundamental Ratings
FOLD
SYRE
OUTLOOK RATING
1..100
8330
VALUATION
overvalued / fair valued / undervalued
1..100
63
Fair valued
72
Overvalued
PROFIT vs RISK RATING
1..100
100100
SMR RATING
1..100
9698
PRICE GROWTH RATING
1..100
5085
P/E GROWTH RATING
1..100
10082
SEASONALITY SCORE
1..100
50n/a

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

FOLD's Valuation (63) in the Biotechnology industry is in the same range as SYRE (72) in the Pharmaceuticals Major industry. This means that FOLD’s stock grew similarly to SYRE’s over the last 12 months.

FOLD's Profit vs Risk Rating (100) in the Biotechnology industry is in the same range as SYRE (100) in the Pharmaceuticals Major industry. This means that FOLD’s stock grew similarly to SYRE’s over the last 12 months.

FOLD's SMR Rating (96) in the Biotechnology industry is in the same range as SYRE (98) in the Pharmaceuticals Major industry. This means that FOLD’s stock grew similarly to SYRE’s over the last 12 months.

FOLD's Price Growth Rating (50) in the Biotechnology industry is somewhat better than the same rating for SYRE (85) in the Pharmaceuticals Major industry. This means that FOLD’s stock grew somewhat faster than SYRE’s over the last 12 months.

SYRE's P/E Growth Rating (82) in the Pharmaceuticals Major industry is in the same range as FOLD (100) in the Biotechnology industry. This means that SYRE’s stock grew similarly to FOLD’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
FOLDSYRE
RSI
ODDS (%)
Bearish Trend 4 days ago
83%
N/A
Stochastic
ODDS (%)
Bearish Trend 4 days ago
89%
Bullish Trend 4 days ago
84%
Momentum
ODDS (%)
N/A
Bearish Trend 4 days ago
88%
MACD
ODDS (%)
Bearish Trend 4 days ago
83%
Bearish Trend 4 days ago
89%
TrendWeek
ODDS (%)
Bullish Trend 4 days ago
71%
Bearish Trend 4 days ago
87%
TrendMonth
ODDS (%)
Bullish Trend 4 days ago
73%
Bearish Trend 4 days ago
89%
Advances
ODDS (%)
Bullish Trend 5 days ago
70%
Bullish Trend 11 days ago
85%
Declines
ODDS (%)
Bearish Trend 7 days ago
77%
Bearish Trend 18 days ago
90%
BollingerBands
ODDS (%)
Bearish Trend 4 days ago
79%
Bullish Trend 4 days ago
80%
Aroon
ODDS (%)
Bullish Trend 4 days ago
78%
N/A
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FOLD
Daily Signalchanged days ago
Gain/Loss if bought
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SYRE
Daily Signalchanged days ago
Gain/Loss if bought
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FOLD and

Correlation & Price change

A.I.dvisor indicates that over the last year, FOLD has been loosely correlated with VCYT. These tickers have moved in lockstep 43% of the time. This A.I.-generated data suggests there is some statistical probability that if FOLD jumps, then VCYT could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To FOLD
1D Price
Change %
FOLD100%
-0.37%
VCYT - FOLD
43%
Loosely correlated
-3.08%
ATXS - FOLD
42%
Loosely correlated
-5.23%
IRON - FOLD
40%
Loosely correlated
-0.78%
SYRE - FOLD
40%
Loosely correlated
-3.40%
ROIV - FOLD
40%
Loosely correlated
-2.29%
More

SYRE and

Correlation & Price change

A.I.dvisor indicates that over the last year, SYRE has been loosely correlated with CGON. These tickers have moved in lockstep 60% of the time. This A.I.-generated data suggests there is some statistical probability that if SYRE jumps, then CGON could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SYRE
1D Price
Change %
SYRE100%
-3.40%
CGON - SYRE
60%
Loosely correlated
+0.54%
IDYA - SYRE
59%
Loosely correlated
-1.28%
BEAM - SYRE
57%
Loosely correlated
-4.41%
XNCR - SYRE
57%
Loosely correlated
+1.18%
CRNX - SYRE
56%
Loosely correlated
+0.80%
More