KRYS
Price
$150.27
Change
+$0.52 (+0.35%)
Updated
Sep 5 closing price
Capitalization
4.35B
63 days until earnings call
SYRE
Price
$17.00
Change
+$0.01 (+0.06%)
Updated
Sep 5 closing price
Capitalization
1.03B
59 days until earnings call
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KRYS vs SYRE

Header iconKRYS vs SYRE Comparison
Open Charts KRYS vs SYREBanner chart's image
Krystal Biotech
Price$150.27
Change+$0.52 (+0.35%)
Volume$324.27K
Capitalization4.35B
Spyre Therapeutics
Price$17.00
Change+$0.01 (+0.06%)
Volume$339.7K
Capitalization1.03B
KRYS vs SYRE Comparison Chart in %
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KRYS
Daily Signalchanged days ago
Gain/Loss if bought
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SYRE
Daily Signalchanged days ago
Gain/Loss if bought
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KRYS vs. SYRE commentary
Sep 08, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is KRYS is a Hold and SYRE is a StrongBuy.

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COMPARISON
Comparison
Sep 08, 2025
Stock price -- (KRYS: $150.27 vs. SYRE: $17.00)
Brand notoriety: KRYS and SYRE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: KRYS: 97% vs. SYRE: 67%
Market capitalization -- KRYS: $4.35B vs. SYRE: $1.03B
KRYS [@Biotechnology] is valued at $4.35B. SYRE’s [@Biotechnology] market capitalization is $1.03B. The market cap for tickers in the [@Biotechnology] industry ranges from $101.56B to $0. The average market capitalization across the [@Biotechnology] industry is $1.92B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

KRYS’s FA Score shows that 0 FA rating(s) are green whileSYRE’s FA Score has 0 green FA rating(s).

  • KRYS’s FA Score: 0 green, 5 red.
  • SYRE’s FA Score: 0 green, 5 red.
According to our system of comparison, KRYS is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

KRYS’s TA Score shows that 7 TA indicator(s) are bullish while SYRE’s TA Score has 7 bullish TA indicator(s).

  • KRYS’s TA Score: 7 bullish, 2 bearish.
  • SYRE’s TA Score: 7 bullish, 2 bearish.
According to our system of comparison, both KRYS and SYRE are a good buy in the short-term.

Price Growth

KRYS (@Biotechnology) experienced а +1.74% price change this week, while SYRE (@Biotechnology) price change was +3.09% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +2.52%. For the same industry, the average monthly price growth was +14.48%, and the average quarterly price growth was +31.71%.

Reported Earning Dates

KRYS is expected to report earnings on Nov 10, 2025.

SYRE is expected to report earnings on Nov 06, 2025.

Industries' Descriptions

@Biotechnology (+2.52% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
KRYS($4.35B) has a higher market cap than SYRE($1.03B). KRYS has higher P/E ratio than SYRE: KRYS (30.54) vs SYRE (1.72). KRYS YTD gains are higher at: -4.079 vs. SYRE (-26.976). KRYS has higher annual earnings (EBITDA): 158M vs. SYRE (-222.15M). KRYS has more cash in the bank: 682M vs. SYRE (527M). SYRE has less debt than KRYS: SYRE (0) vs KRYS (9.68M). KRYS has higher revenues than SYRE: KRYS (359M) vs SYRE (0).
KRYSSYREKRYS / SYRE
Capitalization4.35B1.03B423%
EBITDA158M-222.15M-71%
Gain YTD-4.079-26.97615%
P/E Ratio30.541.721,780%
Revenue359M0-
Total Cash682M527M129%
Total Debt9.68M0-
FUNDAMENTALS RATINGS
KRYS vs SYRE: Fundamental Ratings
KRYS
SYRE
OUTLOOK RATING
1..100
5050
VALUATION
overvalued / fair valued / undervalued
1..100
65
Fair valued
71
Overvalued
PROFIT vs RISK RATING
1..100
38100
SMR RATING
1..100
5397
PRICE GROWTH RATING
1..100
5662
P/E GROWTH RATING
1..100
8982
SEASONALITY SCORE
1..100
9050

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

KRYS's Valuation (65) in the Pharmaceuticals Major industry is in the same range as SYRE (71). This means that KRYS’s stock grew similarly to SYRE’s over the last 12 months.

KRYS's Profit vs Risk Rating (38) in the Pharmaceuticals Major industry is somewhat better than the same rating for SYRE (100). This means that KRYS’s stock grew somewhat faster than SYRE’s over the last 12 months.

KRYS's SMR Rating (53) in the Pharmaceuticals Major industry is somewhat better than the same rating for SYRE (97). This means that KRYS’s stock grew somewhat faster than SYRE’s over the last 12 months.

KRYS's Price Growth Rating (56) in the Pharmaceuticals Major industry is in the same range as SYRE (62). This means that KRYS’s stock grew similarly to SYRE’s over the last 12 months.

SYRE's P/E Growth Rating (82) in the Pharmaceuticals Major industry is in the same range as KRYS (89). This means that SYRE’s stock grew similarly to KRYS’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
KRYSSYRE
RSI
ODDS (%)
N/A
N/A
Stochastic
ODDS (%)
Bearish Trend 3 days ago
83%
Bearish Trend 3 days ago
90%
Momentum
ODDS (%)
Bullish Trend 3 days ago
82%
Bullish Trend 3 days ago
81%
MACD
ODDS (%)
Bullish Trend 3 days ago
81%
Bullish Trend 3 days ago
84%
TrendWeek
ODDS (%)
Bearish Trend 3 days ago
72%
Bullish Trend 3 days ago
84%
TrendMonth
ODDS (%)
Bullish Trend 3 days ago
79%
Bullish Trend 3 days ago
83%
Advances
ODDS (%)
Bullish Trend 5 days ago
78%
Bullish Trend 3 days ago
85%
Declines
ODDS (%)
Bearish Trend 21 days ago
75%
Bearish Trend 10 days ago
90%
BollingerBands
ODDS (%)
Bullish Trend 4 days ago
81%
Bullish Trend 3 days ago
80%
Aroon
ODDS (%)
Bullish Trend 5 days ago
81%
Bullish Trend 4 days ago
82%
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KRYS
Daily Signalchanged days ago
Gain/Loss if bought
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SYRE
Daily Signalchanged days ago
Gain/Loss if bought
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KRYS and

Correlation & Price change

A.I.dvisor indicates that over the last year, KRYS has been loosely correlated with XNCR. These tickers have moved in lockstep 52% of the time. This A.I.-generated data suggests there is some statistical probability that if KRYS jumps, then XNCR could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To KRYS
1D Price
Change %
KRYS100%
+0.35%
XNCR - KRYS
52%
Loosely correlated
+2.15%
SYRE - KRYS
51%
Loosely correlated
+0.06%
CRNX - KRYS
51%
Loosely correlated
+3.97%
CGON - KRYS
49%
Loosely correlated
+6.88%
ACLX - KRYS
49%
Loosely correlated
+0.64%
More

SYRE and

Correlation & Price change

A.I.dvisor indicates that over the last year, SYRE has been loosely correlated with CGON. These tickers have moved in lockstep 61% of the time. This A.I.-generated data suggests there is some statistical probability that if SYRE jumps, then CGON could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SYRE
1D Price
Change %
SYRE100%
+0.06%
CGON - SYRE
61%
Loosely correlated
+6.88%
IDYA - SYRE
61%
Loosely correlated
+5.15%
BEAM - SYRE
57%
Loosely correlated
+12.62%
XNCR - SYRE
57%
Loosely correlated
+2.15%
CRNX - SYRE
56%
Loosely correlated
+3.97%
More