STOK
Price
$30.48
Change
+$3.17 (+11.61%)
Updated
Oct 8, 04:59 PM (EDT)
Capitalization
1.5B
34 days until earnings call
SYRE
Price
$17.70
Change
+$1.68 (+10.49%)
Updated
Oct 8, 04:59 PM (EDT)
Capitalization
967.62M
29 days until earnings call
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STOK vs SYRE

Header iconSTOK vs SYRE Comparison
Open Charts STOK vs SYREBanner chart's image
Stoke Therapeutics
Price$30.48
Change+$3.17 (+11.61%)
Volume$60.76K
Capitalization1.5B
Spyre Therapeutics
Price$17.70
Change+$1.68 (+10.49%)
Volume$19.08K
Capitalization967.62M
STOK vs SYRE Comparison Chart in %
STOK
Daily Signalchanged days ago
Gain/Loss if bought
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SYRE
Daily Signalchanged days ago
Gain/Loss if bought
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STOK vs. SYRE commentary
Oct 09, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is STOK is a StrongBuy and SYRE is a StrongBuy.

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COMPARISON
Comparison
Oct 09, 2025
Stock price -- (STOK: $27.31 vs. SYRE: $16.02)
Brand notoriety: STOK and SYRE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: STOK: 87% vs. SYRE: 80%
Market capitalization -- STOK: $1.5B vs. SYRE: $967.62M
STOK [@Biotechnology] is valued at $1.5B. SYRE’s [@Biotechnology] market capitalization is $967.62M. The market cap for tickers in the [@Biotechnology] industry ranges from $105.19B to $0. The average market capitalization across the [@Biotechnology] industry is $2.05B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

STOK’s FA Score shows that 1 FA rating(s) are green whileSYRE’s FA Score has 0 green FA rating(s).

  • STOK’s FA Score: 1 green, 4 red.
  • SYRE’s FA Score: 0 green, 5 red.
According to our system of comparison, STOK is a better buy in the long-term than SYRE.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

STOK’s TA Score shows that 4 TA indicator(s) are bullish while SYRE’s TA Score has 6 bullish TA indicator(s).

  • STOK’s TA Score: 4 bullish, 4 bearish.
  • SYRE’s TA Score: 6 bullish, 4 bearish.
According to our system of comparison, SYRE is a better buy in the short-term than STOK.

Price Growth

STOK (@Biotechnology) experienced а +16.21% price change this week, while SYRE (@Biotechnology) price change was -4.42% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was +9.11%. For the same industry, the average monthly price growth was +19.03%, and the average quarterly price growth was +87.04%.

Reported Earning Dates

STOK is expected to report earnings on Nov 11, 2025.

SYRE is expected to report earnings on Nov 06, 2025.

Industries' Descriptions

@Biotechnology (+9.11% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
STOK($1.5B) has a higher market cap than SYRE($968M). STOK has higher P/E ratio than SYRE: STOK (31.39) vs SYRE (1.72). STOK YTD gains are higher at: 147.597 vs. SYRE (-31.186). STOK has higher annual earnings (EBITDA): 42.3M vs. SYRE (-222.15M). SYRE has more cash in the bank: 527M vs. STOK (248M). SYRE has less debt than STOK: SYRE (0) vs STOK (2.3M). STOK has higher revenues than SYRE: STOK (200M) vs SYRE (0).
STOKSYRESTOK / SYRE
Capitalization1.5B968M155%
EBITDA42.3M-222.15M-19%
Gain YTD147.597-31.186-473%
P/E Ratio31.391.721,830%
Revenue200M0-
Total Cash248M527M47%
Total Debt2.3M0-
FUNDAMENTALS RATINGS
STOK vs SYRE: Fundamental Ratings
STOK
SYRE
OUTLOOK RATING
1..100
2010
VALUATION
overvalued / fair valued / undervalued
1..100
76
Overvalued
66
Overvalued
PROFIT vs RISK RATING
1..100
100100
SMR RATING
1..100
4698
PRICE GROWTH RATING
1..100
3559
P/E GROWTH RATING
1..100
683
SEASONALITY SCORE
1..100
n/a28

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

SYRE's Valuation (66) in the Pharmaceuticals Major industry is in the same range as STOK (76) in the null industry. This means that SYRE’s stock grew similarly to STOK’s over the last 12 months.

SYRE's Profit vs Risk Rating (100) in the Pharmaceuticals Major industry is in the same range as STOK (100) in the null industry. This means that SYRE’s stock grew similarly to STOK’s over the last 12 months.

STOK's SMR Rating (46) in the null industry is somewhat better than the same rating for SYRE (98) in the Pharmaceuticals Major industry. This means that STOK’s stock grew somewhat faster than SYRE’s over the last 12 months.

STOK's Price Growth Rating (35) in the null industry is in the same range as SYRE (59) in the Pharmaceuticals Major industry. This means that STOK’s stock grew similarly to SYRE’s over the last 12 months.

STOK's P/E Growth Rating (6) in the null industry is significantly better than the same rating for SYRE (83) in the Pharmaceuticals Major industry. This means that STOK’s stock grew significantly faster than SYRE’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
STOKSYRE
RSI
ODDS (%)
Bearish Trend 2 days ago
88%
Bullish Trend 2 days ago
82%
Stochastic
ODDS (%)
Bearish Trend 2 days ago
88%
Bearish Trend 2 days ago
90%
Momentum
ODDS (%)
Bullish Trend 2 days ago
80%
Bullish Trend 2 days ago
78%
MACD
ODDS (%)
Bullish Trend 2 days ago
89%
Bullish Trend 2 days ago
80%
TrendWeek
ODDS (%)
Bullish Trend 2 days ago
84%
Bearish Trend 2 days ago
88%
TrendMonth
ODDS (%)
Bullish Trend 2 days ago
84%
Bearish Trend 2 days ago
89%
Advances
ODDS (%)
Bullish Trend 2 days ago
86%
Bullish Trend 9 days ago
84%
Declines
ODDS (%)
Bearish Trend 16 days ago
84%
Bearish Trend 6 days ago
90%
BollingerBands
ODDS (%)
Bearish Trend 2 days ago
82%
Bullish Trend 2 days ago
85%
Aroon
ODDS (%)
Bullish Trend 2 days ago
82%
Bearish Trend 2 days ago
89%
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STOK
Daily Signalchanged days ago
Gain/Loss if bought
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SYRE
Daily Signalchanged days ago
Gain/Loss if bought
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STOK and

Correlation & Price change

A.I.dvisor indicates that over the last year, STOK has been loosely correlated with QTTB. These tickers have moved in lockstep 49% of the time. This A.I.-generated data suggests there is some statistical probability that if STOK jumps, then QTTB could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To STOK
1D Price
Change %
STOK100%
+1.86%
QTTB - STOK
49%
Loosely correlated
+16.13%
DNLI - STOK
48%
Loosely correlated
-2.10%
SYRE - STOK
47%
Loosely correlated
-3.90%
IDYA - STOK
46%
Loosely correlated
-2.07%
IMNM - STOK
46%
Loosely correlated
-4.09%
More

SYRE and

Correlation & Price change

A.I.dvisor indicates that over the last year, SYRE has been loosely correlated with CGON. These tickers have moved in lockstep 58% of the time. This A.I.-generated data suggests there is some statistical probability that if SYRE jumps, then CGON could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To SYRE
1D Price
Change %
SYRE100%
-3.90%
CGON - SYRE
58%
Loosely correlated
-0.34%
IDYA - SYRE
57%
Loosely correlated
-2.07%
XNCR - SYRE
56%
Loosely correlated
+2.04%
APGE - SYRE
56%
Loosely correlated
-0.23%
RGNX - SYRE
55%
Loosely correlated
-1.68%
More