SPRO
Price
$2.38
Change
-$0.09 (-3.64%)
Updated
Nov 19, 04:59 PM (EDT)
Capitalization
134.09M
127 days until earnings call
Intraday BUY SELL Signals
XENE
Price
$40.67
Change
+$0.06 (+0.15%)
Updated
Nov 19, 04:59 PM (EDT)
Capitalization
3.14B
99 days until earnings call
Intraday BUY SELL Signals
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SPRO vs XENE

Header iconSPRO vs XENE Comparison
Open Charts SPRO vs XENEBanner chart's image
Spero Therapeutics
Price$2.38
Change-$0.09 (-3.64%)
Volume$67.32K
Capitalization134.09M
Xenon Pharmaceuticals
Price$40.67
Change+$0.06 (+0.15%)
Volume$20.03K
Capitalization3.14B
SPRO vs XENE Comparison Chart in %
SPRO
Daily Signal:
Gain/Loss:
XENE
Daily Signal:
Gain/Loss:
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SPRO vs. XENE commentary
Nov 20, 2025

To compare these two companies we present long-term analysis, their fundamental ratings and make comparative short-term technical analysis which are presented below. The conclusion is SPRO is a Hold and XENE is a Hold.

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COMPARISON
Comparison
Nov 20, 2025
Stock price -- (SPRO: $2.46 vs. XENE: $40.61)
Brand notoriety: SPRO and XENE are both not notable
Both companies represent the Biotechnology industry
Current volume relative to the 65-day Moving Average: SPRO: 44% vs. XENE: 107%
Market capitalization -- SPRO: $134.09M vs. XENE: $3.14B
SPRO [@Biotechnology] is valued at $134.09M. XENE’s [@Biotechnology] market capitalization is $3.14B. The market cap for tickers in the [@Biotechnology] industry ranges from $106.82B to $0. The average market capitalization across the [@Biotechnology] industry is $2.15B.

Long-Term Analysis

It is best to consider a long-term outlook for a ticker by using Fundamental Analysis (FA) ratings. The rating of 1 to 100, where 1 is best and 100 is worst, is divided into thirds. The first third (a green rating of 1-33) indicates that the ticker is undervalued; the second third (a grey number between 34 and 66) means that the ticker is valued fairly; and the last third (red number of 67 to 100) reflects that the ticker is undervalued. We use an FA Score to show how many ratings show the ticker to be undervalued (green) or overvalued (red).

SPRO’s FA Score shows that 1 FA rating(s) are green whileXENE’s FA Score has 1 green FA rating(s).

  • SPRO’s FA Score: 1 green, 4 red.
  • XENE’s FA Score: 1 green, 4 red.
According to our system of comparison, XENE is a better buy in the long-term than SPRO.

Short-Term Analysis

It is best to consider a short-term outlook for a ticker by using Technical Analysis (TA) indicators. We use Odds of Success as the percentage of outcomes which confirm successful trade signals in the past.

If the Odds of Success (the likelihood of the continuation of a trend) for each indicator are greater than 50%, then the generated signal is confirmed. A green percentage from 90% to 51% indicates that the ticker is in a bullish trend. A red percentage from 90% - 51% indicates that the ticker is in a bearish trend. All grey percentages are below 50% and are considered not to confirm the trend signal.

SPRO’s TA Score shows that 3 TA indicator(s) are bullish while XENE’s TA Score has 4 bullish TA indicator(s).

  • SPRO’s TA Score: 3 bullish, 4 bearish.
  • XENE’s TA Score: 4 bullish, 6 bearish.
According to our system of comparison, SPRO is a better buy in the short-term than XENE.

Price Growth

SPRO (@Biotechnology) experienced а -5.92% price change this week, while XENE (@Biotechnology) price change was +1.73% for the same time period.

The average weekly price growth across all stocks in the @Biotechnology industry was -2.17%. For the same industry, the average monthly price growth was -5.68%, and the average quarterly price growth was +64.91%.

Reported Earning Dates

SPRO is expected to report earnings on Mar 26, 2026.

XENE is expected to report earnings on Feb 26, 2026.

Industries' Descriptions

@Biotechnology (-2.17% weekly)

Biotechnology involves genetic or protein engineering to produce medicines/therapies for treating and preventing ailments. The industry also provides crucial ingredients for diagnostics. This multi-billion-dollar industry is heavily focused on research and development, as companies attempt to continually come up with cutting-edge solutions for health. New discoveries for the treatment of diseases provide opportunities for growth for a company in this industry. Discoveries, however, must pass the regulatory approval from the U.S. Food and Drug Administration (FDA) before they can make it to markets. Amgen Inc., Gilead Sciences, Inc. and Celgene Corporation are examples of companies in this industry.

SUMMARIES
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FUNDAMENTALS
Fundamentals
XENE($3.14B) has a higher market cap than SPRO($134M). SPRO YTD gains are higher at: 139.320 vs. XENE (3.597). SPRO has higher annual earnings (EBITDA): -56.36M vs. XENE (-315.5M). XENE has more cash in the bank: 488M vs. SPRO (31.2M). SPRO has less debt than XENE: SPRO (3.62M) vs XENE (8.72M). SPRO has higher revenues than XENE: SPRO (34.1M) vs XENE (7.5M).
SPROXENESPRO / XENE
Capitalization134M3.14B4%
EBITDA-56.36M-315.5M18%
Gain YTD139.3203.5973,873%
P/E Ratio10.75N/A-
Revenue34.1M7.5M455%
Total Cash31.2M488M6%
Total Debt3.62M8.72M41%
FUNDAMENTALS RATINGS
SPRO vs XENE: Fundamental Ratings
SPRO
XENE
OUTLOOK RATING
1..100
2663
VALUATION
overvalued / fair valued / undervalued
1..100
60
Fair valued
73
Overvalued
PROFIT vs RISK RATING
1..100
10034
SMR RATING
1..100
9895
PRICE GROWTH RATING
1..100
3548
P/E GROWTH RATING
1..100
55
SEASONALITY SCORE
1..100
5085

Tickeron ratings are formulated such that a rating of 1 designates the most successful stocks in a given industry, while a rating of 100 points to the least successful stocks for that industry.

SPRO's Valuation (60) in the Pharmaceuticals Major industry is in the same range as XENE (73) in the Biotechnology industry. This means that SPRO’s stock grew similarly to XENE’s over the last 12 months.

XENE's Profit vs Risk Rating (34) in the Biotechnology industry is significantly better than the same rating for SPRO (100) in the Pharmaceuticals Major industry. This means that XENE’s stock grew significantly faster than SPRO’s over the last 12 months.

XENE's SMR Rating (95) in the Biotechnology industry is in the same range as SPRO (98) in the Pharmaceuticals Major industry. This means that XENE’s stock grew similarly to SPRO’s over the last 12 months.

SPRO's Price Growth Rating (35) in the Pharmaceuticals Major industry is in the same range as XENE (48) in the Biotechnology industry. This means that SPRO’s stock grew similarly to XENE’s over the last 12 months.

SPRO's P/E Growth Rating (5) in the Pharmaceuticals Major industry is in the same range as XENE (5) in the Biotechnology industry. This means that SPRO’s stock grew similarly to XENE’s over the last 12 months.

TECHNICAL ANALYSIS
Technical Analysis
SPROXENE
RSI
ODDS (%)
Bearish Trend 2 days ago
90%
Bearish Trend 2 days ago
59%
Stochastic
ODDS (%)
Bullish Trend 2 days ago
79%
Bearish Trend 2 days ago
86%
Momentum
ODDS (%)
Bullish Trend 2 days ago
70%
Bullish Trend 2 days ago
75%
MACD
ODDS (%)
Bearish Trend 2 days ago
89%
Bearish Trend 2 days ago
74%
TrendWeek
ODDS (%)
Bearish Trend 2 days ago
89%
Bullish Trend 2 days ago
75%
TrendMonth
ODDS (%)
Bullish Trend 2 days ago
74%
Bearish Trend 2 days ago
73%
Advances
ODDS (%)
Bullish Trend 2 days ago
70%
Bullish Trend 6 days ago
72%
Declines
ODDS (%)
Bearish Trend 6 days ago
90%
Bearish Trend 13 days ago
70%
BollingerBands
ODDS (%)
Bearish Trend 2 days ago
82%
Bullish Trend 2 days ago
77%
Aroon
ODDS (%)
N/A
Bearish Trend 2 days ago
72%
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SPRO
Daily Signal:
Gain/Loss:
XENE
Daily Signal:
Gain/Loss:
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XENE and

Correlation & Price change

A.I.dvisor indicates that over the last year, XENE has been loosely correlated with NUVL. These tickers have moved in lockstep 59% of the time. This A.I.-generated data suggests there is some statistical probability that if XENE jumps, then NUVL could also see price increases.

1D
1W
1M
1Q
6M
1Y
5Y
Ticker /
NAME
Correlation
To XENE
1D Price
Change %
XENE100%
N/A
NUVL - XENE
59%
Loosely correlated
-3.48%
IDYA - XENE
58%
Loosely correlated
+1.08%
NRIX - XENE
54%
Loosely correlated
-1.02%
DNLI - XENE
52%
Loosely correlated
+0.58%
CRNX - XENE
51%
Loosely correlated
-1.17%
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