AN2 Therapeutics Inc is a biopharmaceutical company focused on discovering and developing novel small molecule therapeutics derived from its boron chemistry platform... Show more
AN2 Therapeutics, Inc. (ANTX) is a biopharmaceutical company specializing in novel small molecule therapeutics derived from its proprietary boron chemistry platform. Headquartered in Menlo Park, California, the firm focuses on underserved areas like infectious diseases, with lead candidate epetraborole in Phase 3 trials for non-tuberculous mycobacterial (NTM) lung disease and acute melioidosis. Additional pipeline assets include AN2-502998 for chronic Chagas disease in preclinical stages, plus programs in oncology.
AN2 operates in the competitive biotechnology industry, leveraging licensing deals with Anacor Pharmaceuticals, Brii Biosciences, and GSK for tuberculosis therapies. Its fundamentals—emphasizing boron-based inhibitors—position it well for breakthroughs in resistant infections, explaining recent stock price resilience amid clinical milestones that drive market trends.
Over the last 30 days, ANTX stock climbed from approximately $1.06 to $3.42, marking a +223% gain. The movement was highly volatile and trend-driven, highlighted by multi-day surges exceeding 100% following key announcements, before modest pullbacks.
For the quarter, shares advanced +208% from around $1.11 to $3.42. Performance featured steady early gains accelerating into sharp rallies, characteristic of biotech stocks reacting to pipeline news, with range-bound periods interspersed by high-volume spikes.
The 30-day rally stemmed primarily from pipeline catalysts. On March 3, AN2 announced plans to advance oral epetraborole into a Phase 2 study for Polycythemia Vera (PV), a blood disorder, sparking initial optimism. This was amplified on March 9 by a $40 million private placement financing, selling shares at $2.85 and warrants, providing runway for trials—shares doubled that day amid biggest-ever gains.
March 17 brought Q4 2025 results, reporting EPS of -$0.29 versus -$0.25 last year, but highlighting scientific progress. Option repricing on March 20 aided retention. The March 31 Phase 2 initiation for Mycobacterium abscessus lung disease sustained momentum, boosting sentiment in stock price analysis despite volatility.
Quarterly gains built on sustained narratives around epetraborole's expansion. Early January FDA clearance for a 90-patient investigator-initiated trial (IIT) in M. abscessus lung disease laid groundwork. January leadership adjustments and conference participation enhanced visibility.
Biotech industry trends favoring infectious disease innovators, coupled with AN2's boron platform differentiation, drew institutional interest like Commodore Capital's stake. Macro factors, including healthcare funding amid regulatory stability, supported cumulative impact, with financing and trial news as strongest drivers of price movement.
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Investors should monitor upcoming Phase 2 data readouts for epetraborole in PV and M. abscessus lung disease, alongside progress in NTM Phase 3 trials. Q1 2026 earnings and cash burn post-financing will gauge financial health.
Industry trends in infectious diseases, potential partnerships expanding the boron platform, and macroeconomic shifts like biotech funding or FDA decisions remain key. Risks include trial setbacks; catalysts could involve oncology updates or regulatory milestones affecting sentiment.
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The 10-day moving average for ANTX crossed bullishly above the 50-day moving average on June 12, 2026. This indicates that the trend has shifted higher and could be considered a buy signal. In of 12 past instances when the 10-day crossed above the 50-day, the stock continued to move higher over the following month. The odds of a continued upward trend are .
The Momentum Indicator moved above the 0 level on June 12, 2026. You may want to consider a long position or call options on ANTX as a result. In of 68 past instances where the momentum indicator moved above 0, the stock continued to climb. The odds of a continued upward trend are .
The Moving Average Convergence Divergence (MACD) for ANTX just turned positive on June 12, 2026. Looking at past instances where ANTX's MACD turned positive, the stock continued to rise in of 28 cases over the following month. The odds of a continued upward trend are .
ANTX moved above its 50-day moving average on June 10, 2026 date and that indicates a change from a downward trend to an upward trend.
Following a +1 3-day Advance, the price is estimated to grow further. Considering data from situations where ANTX advanced for three days, in of 216 cases, the price rose further within the following month. The odds of a continued upward trend are .
ANTX may jump back above the lower band and head toward the middle band. Traders may consider buying the stock or exploring call options.
The Aroon Indicator entered an Uptrend today. In of 99 cases where ANTX Aroon's Indicator entered an Uptrend, the price rose further within the following month. The odds of a continued Uptrend are .
The Stochastic Oscillator entered the overbought zone. Expect a price pull-back in the foreseeable future.
Following a 3-day decline, the stock is projected to fall further. Considering past instances where ANTX declined for three days, the price rose further in of 62 cases within the following month. The odds of a continued downward trend are .
The Tickeron Valuation Rating of (best 1 - 100 worst) indicates that the company is slightly undervalued in the industry. This rating compares market capitalization estimated by our proprietary formula with the current market capitalization. This rating is based on the following metrics, as compared to industry averages: P/B Ratio (2.088) is normal, around the industry mean (18.720). P/E Ratio (0.000) is within average values for comparable stocks, (36.072). Projected Growth (PEG Ratio) (0.000) is also within normal values, averaging (1.682). ANTX has a moderately low Dividend Yield (0.000) as compared to the industry average of (0.038). P/S Ratio (0.000) is also within normal values, averaging (357.550).
The Tickeron Price Growth Rating for this company is (best 1 - 100 worst), indicating steady price growth. ANTX’s price grows at a higher rate over the last 12 months as compared to S&P 500 index constituents.
The Tickeron Seasonality Score of (best 1 - 100 worst) indicates that the company is fair valued in the industry. The Tickeron Seasonality score describes the variance of predictable price changes around the same period every calendar year. These changes can be tied to a specific month, quarter, holiday or vacation period, as well as a meteorological or growing season.
The Tickeron SMR rating for this company is (best 1 - 100 worst), indicating weak sales and an unprofitable business model. SMR (Sales, Margin, Return on Equity) rating is based on comparative analysis of weighted Sales, Income Margin and Return on Equity values compared against S&P 500 index constituents. The weighted SMR value is a proprietary formula developed by Tickeron and represents an overall profitability measure for a stock.
The Tickeron PE Growth Rating for this company is (best 1 - 100 worst), pointing to worse than average earnings growth. The PE Growth rating is based on a comparative analysis of stock PE ratio increase over the last 12 months compared against S&P 500 index constituents.
The Tickeron Profit vs. Risk Rating rating for this company is (best 1 - 100 worst), indicating that the returns do not compensate for the risks. ANTX’s unstable profits reported over time resulted in significant Drawdowns within these last five years. A stable profit reduces stock drawdown and volatility. The average Profit vs. Risk Rating rating for the industry is 94, placing this stock worse than average.
The average fundamental analysis ratings, where 1 is best and 100 is worst, are as follows
Industry Biotechnology