Principia Biopharma (PRNB) Knocks on Big...

Steven Orlowski

published in Blogs

Oct 24, 2018

Principia Biopharma (PRNB) Knocks on Big Pharma’s Door

Principia Biopharma continued its impressive progress with its recent initial public offering on September 14, 2018. Principia Biopharma (Nasdaq: PRNB) has developed three drug candidates in immunology, central nervous system disorders, and oncology.

The company is utilizing 'Tailored Covalency,' its proprietary drug discovery platform, to discover new drugs that combine the dosing ability of an oral small molecule drug with the specificity of an antibody.

Standard small molecule drugs have a short duration of time that the drug binds to its target, called residence time, that require dosing regimens to maintain target concentration levels in the blood to get the desired result.

Principia has designed its drugs to remain bound to the target, and clear the body rapidly, to optimize residence time. According to the company this will minimize adverse effects while achieving the desired benefit.

PRN1008 is being developed for multiple autoimmune diseases. The Phase 2 study of PRN1008 for use in treating pemphigus, a chronic disorder that cause blisters and sores on the skin or mucous membranes, is forthcoming.

Principia has partnered with Sanofi SNY in an exclusive, global licensing agreement to develop and commercialize PRN2246 for multiple sclerosis. Sanofi paid Principia $40 million upfront and agreed to future milestone payments that have the potential to amount to $765 million on top of royalties.

The stock is down approximately 25% since its IPO which may be the result of post-IPO selloff and not a reflection of the company’s prospects. At $24.00 versus its opening day high of $32.65, Principia Biopharma might be occupying a price range opportunity for savvy investors.

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Sergey Savastiouk

published in Blogs

Mar 07, 2021

4 Tricks Hedge Funds Use to Get Ahead

If the stock market were Major League Baseball, hedge funds and institutional investors would be the pros on championship teams while everyday self-directed investors (SDIs) are the benchwarmers in the minors.It’s how they get ahead, and it’s why 90% of SDIs lose money trying to play (invest and trade) in the major leagues. The 4 tricks we discuss below are rooted in one common theme: they all use Artificial Intelligence and algorithms to generate data and ideas.

John Jacques

published in Blogs

Mar 22, 2018

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Statistics for the Head-and-Shoulders Bottom Pattern The days where only hedge funds used algorithms to trade stocks are officially over. Now retail investors can use Artificial Intelligence (A.I. Here’s an example of the algorithm in action: Late last year, Tickeron’s A.I.

Sergey Savastiouk

published in Blogs

Jul 10, 2020

3 Stocks to Buy if Coronavirus Second Wave Hits

By analyzing market trends from the first wave, you can predict behavior for the second. Technology stocks have performed at historic levels this year, but the market is severely overbought.To compensate for that, look at performance during Q1 and Q2, the height of global Covid shutdowns.

Edward Flores

published in Blogs

Feb 06, 2021

How to Become the Millionaire Next Door

The Golden Gate Bridge is always a fixture of these walks too, one of man's most beautiful creations. As we were walking, at one point she turned to me and said, "Man, I'll never have a million dollars."" My girlfriend is 27 years old and works as a graphic designer, making about $75,000 a year.

Alla Petriaieva

published in Blogs

Feb 23, 2021

Is Ethereum’s Bomb about to Explode?

Ethereum’s software is set for an update in October.Until it is finished, participants in the Ethereum blockchain must determine how to delay the difficulty bomb – code that necessitates a steadily increasing amount of computer power to mine blocks and unlock rewards – that is already in place.

Sergey Savastiouk

published in Blogs

Aug 07, 2018

When Is the Next Recession Coming?

However, we also know that economists predicted 22 recessions out of 11 that took place since 1945. Are there real recession signs we should watch for?Indeed, the answer is yes, and here are a few very important ones: The first one is almost obvious and known to everyone – it is the Fed.

Abhoy Sarkar

published in Blogs

May 22, 2020

Central banks have been buying $2.4 billion in assets every hour for the past two months

Some $17.8 billion has been poured into bond markets over the past week, the biggest move in more than three months.Around $3.5 billion has been invested into gold, the second largest on record.

Rick Pendergraft

published in Blogs

Feb 07, 2021

Mid-January Short Interest Report Shows 8 Stocks with Good Fundamentals and High Short Interest

Sergey Savastiouk

published in Blogs

Mar 10, 2021

How to Start Trading Penny Stocks

Penny stocks have long been marginalized within the professional investment community, oftentimes being painted with a broad brush of simply being “too risky.” Leonardo DiCaprio’s depiction of the penny stock peddling conman, Jordan Belfort, in the Wolf of Wall Street certainly didn’t help.Here are four reasons to start trading them now. Reason #1: Let’s State the Obvious -- Penny Stocks are Cheap A single share of Apple Inc. costs over $350.

Abhoy Sarkar

published in Blogs

May 08, 2020

US unemployment rate jumps to 14.7%, the highest in series history

The U.S. economy’s employment fell by -20.5 million in April. The coronavirus crisis led to unemployment rate soaring to 14.7% in the U.S, the highest rate in the Bureau of Labor Statistics-tracked series history that goes back to 1948. However, the figures were better compared to several economists'/analysts' forecasts of 22 million job losses and 16% unemployment rate. Another unemployment measure that includes those who have stopped looking for work as well as those holding part-time jobs for economic reasons also touched an all-time high of 22.8%.